Drugs for Endometriosis and Uterine Fibroids
The 2026 treatment landscape emphasizes GnRH antagonists, which provide rapid relief from pain and heavy bleeding with a more manageable side-effect profile than older therapies.
GnRH Antagonists: Elagolix (Orilissa) and Relugolix (Myfembree) are leading oral treatments that suppress estrogen production to shrink fibroids and endometriosis lesions.
GnRH Agonists: Goserelin (Zoladex) and Leuprorelin, typically administered via injection to induce a temporary state of menopause.
Progestins: High-dose Norethisterone or Dienogest used specifically to thin the endometrial lining.
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